CCNE1 amplification is associated with poor prognosis in patients with triple negative breast cancer.

ABSTRACT:

Background

Triple negative breast cancer (TNBC) is aggressive with limited treatment options upon recurrence. Molecular discordance between primary and metastatic TNBC has been observed, but the degree of biological heterogeneity has not been fully explored. Furthermore, genomic evolution through treatment is poorly understood. In this study, we aim to characterize the genomic changes between paired primary and metastatic TNBCs through transcriptomic and genomic profiling, and to identify genomic alterations which may contribute to chemotherapy resistance.

Methods

Genomic alterations and mRNA expression of 10 paired primary and metastatic TNBCs were determined through targeted sequencing, microarray analysis, and RNA sequencing. Commonly mutated genes, as well as differentia

SUBMITTER: Zhao ZM 

PROVIDER: S-EPMC6341717 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature