Transcriptionally induced enhancers in the macrophage immune response to Mycobacterium tuberculosis infection.

ABSTRACT:

Background

Tuberculosis is a life-threatening infectious disease caused by Mycobacterium tuberculosis (M.tb). M.tb subverts host immune responses to build a favourable niche and survive inside of host macrophages. Macrophages can control or eliminate the infection, if acquire appropriate functional phenotypes. Transcriptional regulation is a key process that governs the activation and maintenance of these phenotypes. Among the factors orchestrating transcriptional regulation during M.tb infection, transcriptional enhancers still remain unexplored.

Results

We analysed transcribed enhancers in M.tb-infected mouse bone marrow-derived macrophages. We established a link between known M.tb-responsive transcription factors and transcriptional activation of enhancers and their targe

SUBMITTER: Denisenko E 

PROVIDER: S-EPMC6341744 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature