Impaired olfaction and other prodromal features in the Parkinson At-Risk Syndrome Study.

ABSTRACT: To test the association between impaired olfaction and other prodromal features of PD in the Parkinson At-Risk Syndrome Study. The onset of olfactory dysfunction in PD typically precedes motor features, suggesting that olfactory testing could be used as a screening test. A combined strategy that uses other prodromal nonmotor features, along with olfactory testing, may be more efficient than hyposmia alone for detecting the risk of PD. Individuals with no neurological diagnosis completed a mail survey, including the 40-item University of Pennsylvania Smell Identification Test, and questions on prodromal features of PD. The frequency of reported nonmotor features was compared across individuals with and without hyposmia. A total of 4,999 subjects completed and returned the survey and smell t

SUBMITTER: Siderowf A 

PROVIDER: S-EPMC6342466 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature