Treatment of endometriosis-related chronic pelvic pain with Ulipristal Acetate and associated endometrial changes.

ABSTRACT:

Background

Aberrant progesterone signaling has been demonstrated in mechanistic studies to be a shared common pathway in fibroids and endometriosis. Progesterone receptor modulation with the selective progesterone receptor modulator (SPRM) ulipristal may decrease pain associated with endometriosis.

Case

A 25-year-old nulligravidae with endometriosis-related pelvic pain refractory to medical and surgical intervention was administered 15mg ulipristal every other day for 3 months. Daily pain scores and bleeding diary were recorded and serum chemistries and hormone levels were checked prior to, during, and after treatment. Pre-treatment and surveillance endometrial biopsy specimens were examined for histology and stained for estrogen and progesterone receptor status. During ther

SUBMITTER: Bressler LH 

PROVIDER: S-EPMC6342495 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature