Cognitive function impacts gait, functional mobility and falls in fragile X-associated tremor/ataxia syndrome.

ABSTRACT:

Background

Executive function and information processing speed deficits occur in fragile X premutation carriers (PMC) with and without fragile X-associated tremor/ataxia syndrome (FXTAS). Gait is negatively impacted by cognitive deficits in many patient populations resulting in increased morbidity and falls but these relationships have not been studied in FXTAS.

Research question

We sought to investigate the associations between executive function and information processing speed and gait, turning and falls in PMC with and without FXTAS compared to healthy controls.

Methods

Global cognition and the cognitive domains of information processing speed, attention, response inhibition, working memory and verbal fluency were tested with a neuropsychological test battery in 1

SUBMITTER: O'Keefe JA 

PROVIDER: S-EPMC6342509 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature