Activation of fibroblastic reticular cells in kidney lymph node during crescentic glomerulonephritis.

ABSTRACT: Crescentic glomerulonephritis is an inflammatory condition characterized by rapid deterioration of kidney function. Previous studies of crescentic glomerulonephritis have focused on immune activation in the kidney. However, the role of fibroblastic reticular cells, which reside in the stromal compartment of the kidney lymph node, has not been studied in this condition. We investigated the activation of kidney lymph node-resident fibroblastic reticular cells in nephrotoxic serum nephritis, a classic murine model of crescentic glomerulonephritis. We found that increased deposition of extracellular matrix fibers by fibroblastic reticular cells in the kidney lymph node was associated with the propagation of high endothelial venules, specialized blood vessels through which lymphocytes enter the

SUBMITTER: Kasinath V 

PROVIDER: S-EPMC6342621 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature