Magnetic resonance T1w/T2w ratio: A parsimonious marker for Parkinson disease.

ABSTRACT:

Objective

Newer magnetic resonance imaging (MRI) techniques have shown promise in capturing early Parkinson disease (PD)-related changes in the substantia nigra pars compacta (SNc), the key pathological loci. Their translational value, however, is hindered by technical complexity and inconsistent results.

Methods

A novel yet simple MRI contrast, the T1w/T2w ratio, was used to study 76 PD patients and 70 controls. The T1w/T2w ratio maps were analyzed using both voxel-based and region-of-interest approaches in normalized space. The sensitivity and specificity of the SNc T1w/T2w ratio in discriminating between PD and controls also were assessed. In addition, its diagnostic performance was tested in a subgroup of PD patients with disease duration ≤2 years (PDE). A second indepen

SUBMITTER: Du G 

PROVIDER: S-EPMC6342624 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature