Cumulative childhood risk is associated with a new measure of chronic inflammation in adulthood.

ABSTRACT:

Background

Childhood risk factors are associated with elevated inflammatory biomarkers in adulthood, but it is unknown whether these risk factors are associated with increased adult levels of the chronic inflammation marker soluble urokinase plasminogen activator receptor (suPAR). We aimed to test the hypothesis that childhood exposure to risk factors for adult disease is associated with elevated suPAR in adulthood and to compare suPAR with the oft-reported inflammatory biomarker C-reactive protein (CRP).

Methods

Prospective study of a population-representative 1972-1973 birth cohort; the Dunedin Multidisciplinary Health and Development Study observed participants to age 38 years. Main childhood predictors were poor health, socioeconomic disadvantage, adverse childhood exper

SUBMITTER: Rasmussen LJH 

PROVIDER: S-EPMC6342676 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature