Analysis of Individual Case Safety Reports of Severe Cutaneous Adverse Reactions in Korea.

ABSTRACT:

Purpose

Despite morbidities and fatalities, nationwide epidemiologic data for severe cutaneous adverse reactions (SCARs), including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS), are not widely available. We aimed to investigate SCAR epidemiology over the last two decades in Korea.

Materials and methods

We analyzed individual case safety reports (ICSRs) of SCARs in the Korea Adverse Event Reporting System from 1988 to 2013. Administered drugs, demographic profiles, and causality assessment according to the World Health Organization-Uppsala Monitoring Center system were analyzed.

Results

A total of 755 SCAR cases (508 SJS/TEN, 247 DRESS) were reported. The number of SCAR ICSRs has bee

SUBMITTER: Kang MG 

PROVIDER: S-EPMC6342723 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature