Transcriptomic immaturity inducible by neural hyperexcitation is shared by multiple neuropsychiatric disorders.

ABSTRACT: Biomarkers are needed to improve the diagnosis of neuropsychiatric disorders, which are often associated to excitatory/inhibitory imbalances in neural transmission and abnormal maturation. Here, we characterized different disease conditions by mapping changes in the expression patterns of maturation-related genes whose expression was altered by experimental neural hyperexcitation in published studies. This analysis revealed two gene expression patterns: decreases in maturity markers and increases in immaturity markers. These two groups of genes were characterized by the over-representation of genes related to synaptic function and chromosomal modification, respectively. Using these two groups in a transdiagnostic analysis of 87 disease datasets for eight neuropsychiatric disorders and 12 d

SUBMITTER: Murano T 

PROVIDER: S-EPMC6342824 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature