The consistency of neuropathological diagnoses in patients undergoing surgery for suspected recurrence of glioblastoma.

ABSTRACT:

Purpose

Clinical factors and neuro-imaging in patients with glioblastoma who appear to progress following standard chemoradiation are unable to reliably distinguish tumor progression from pseudo-progression. As a result, surgery is commonly recommended to establish a final diagnosis. However, studies evaluating the pathologists' agreement on pathologic diagnoses in this setting have not been previously evaluated.

Methods

A hypothetical clinical history coupled with images of histological sections from 13 patients with glioblastoma who underwent diagnostic surgery for suspected early recurrence were sent to 101 pathologists from 50 NCI-designated Cancer Centers. Pathologists were asked to provide a final diagnosis (active tumor, treatment effect, or unable to classify) and to

SUBMITTER: Holdhoff M 

PROVIDER: S-EPMC6342857 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature