Propofol-sparing effect of different concentrations of dexmedetomidine : Comparison of gender differences.

ABSTRACT:

Background

The pharmacodynamics of propofol are closely linked to gender. Dexmedetomidine can decrease propofol needs during propofol anesthesia. The aim of this study was to compare the gender differences on the calculated effect site median effective concentration (EC₅₀) of propofol for loss of consciousness (LOC) after pretreatment with different concentrations of dexmedetomidine.

Methods

In this study 60 male and 60 female patients were randomly allocated to receive dexmedetomidine at target plasma concentrations of 0.0 ng/ml (0.0 group), 0.4 ng/ml (0.4 group), 0.6 ng/ml (0.6 group) and 0.8 ng/ml (0.8 group). Propofol was administered after dexmedetomidine had been intravenously infused for 15 min. The propofol infusion was targeted to provide an initial effec

SUBMITTER: Xiong M 

PROVIDER: S-EPMC6342900 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature