Increased risk of second cancers at sites associated with HPV after a prior HPV-associated malignancy, a systematic review and meta-analysis.

ABSTRACT:

Background

High-risk human papilloma viruses (HPV) are a causative agent of anogenital and oropharyngeal cancers. Patients treated for a preinvasive or invasive HPV-associated cancer may be at increased risk of a second such malignancy.

Methods

We performed a systematic review and random effects meta-analysis to estimate the risk of HPV-associated cancer after prior diagnosis. Studies reporting second cancers at anogenital and oropharyngeal sites after prior diagnoses (preinvasive/invasive HPV-associated cancer) were identified. Studies reporting standardised incidence ratios (SIRs) were included in formal meta-analyses of second cancer risk. (PROSPERO ID: CRD42016046974).

Results

Searches returned 5599 titles, including 60 unique, eligible studies. Thirty-two (98 com

SUBMITTER: Gilbert DC 

PROVIDER: S-EPMC6342987 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature