Mendelian randomization provides support for obesity as a risk factor for meningioma.

ABSTRACT: Little is known about the causes of meningioma. Obesity and obesity-related traits have been reported in several epidemiological observational studies to be risk factors for meningioma. We performed an analysis of genetic variants associated with obesity-related traits to assess the relationship with meningioma risk using Mendelian randomization (MR), an approach unaffected by biases from temporal variability and reverse causation that might have affected earlier investigations. We considered 11 obesity-related traits, identified genetic instruments for these factors, and assessed their association with meningioma risk using data from a genome-wide association study comprising 1,606 meningioma patients and 9,823 controls. To evaluate the causal relationship between the obesity-related trai

SUBMITTER: Takahashi H 

PROVIDER: S-EPMC6343031 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature