Towards comprehensive annotation of Drosophila melanogaster enzymes in FlyBase.

ABSTRACT: The catalytic activities of enzymes can be described using Gene Ontology (GO) terms and Enzyme Commission (EC) numbers. These annotations are available from numerous biological databases and are routinely accessed by researchers and bioinformaticians to direct their work. However, enzyme data may not be congruent between different resources, while the origin, quality and genomic coverage of these data within any one resource are often unclear. GO/EC annotations are assigned either manually by expert curators or inferred computationally, and there is potential for errors in both types of annotation. If such errors remain unchecked, false positive annotations may be propagated across multiple resources, significantly degrading the quality and usefulness of these data. Similarly, the absence

SUBMITTER: Garapati PV 

PROVIDER: S-EPMC6343044 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature