Association of myocardial fibrosis and cardiovascular events: the multi-ethnic study of atherosclerosis.

ABSTRACT:

Aims

We used contrast-enhanced cardiac magnetic resonance (CMR) to evaluate differences in myocardial fibrosis measured at the year-10 examination between participants with and without cardiovascular (CV) events accrued in a large population based study over the preceding 10-year follow-up period in this retrospective study.

Methods and results

The MESA study enrolled 6814 participants free of CV disease at baseline (2000-2002). We included MESA participants who underwent contrast-enhanced CMR at the MESA year-10 exam (N = 1840). We defined a composite CV endpoint of coronary heart disease, heart failure, atrial fibrillation, stroke, and peripheral artery disease. Using CMR, we characterized myocardial fibrosis with late-gadolinium enhancement for scar and T1 mapping indices

SUBMITTER: Ambale-Venkatesh B 

PROVIDER: S-EPMC6343084 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature