Effects of positive acceleration (+Gz stress) on liver enzymes, energy metabolism, and liver histology in rats.

ABSTRACT:

Background

Exposure to high sustained +Gz (head-to-foot inertial load) is known to have harmful effects on pilots' body in flight. Although clinical data have shown that liver dysfunction occurs in pilots, the precise cause has not been well defined.

Aim

To investigate rat liver function changes in response to repeated +Gz exposure.

Methods

Ninety male Wistar rats were randomly divided into a blank control group (BC group, n = 30), a +6 Gz/5 min stress group (6GS group, n = 30), and a +10 Gz/5min stress group (10GS group, n = 30). The 6GS and 10GS groups were exposed to +6 Gz and +10 Gz, respectively, in an animal centrifuge. The onset rate of +Gz was 0.5 G/s. The sustained time at peak +Gz was 5 min for each exposure (for 5 exposures, and 5-min i

SUBMITTER: Shi B 

PROVIDER: S-EPMC6343093 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature