Effect of Cilostazol on the Pharmacokinetics of Simvastatin in Healthy Subjects.

ABSTRACT:

Purpose

We evaluated potential drug-drug interactions between cilostazol and simvastatin, both CYP3A substrates, in healthy subjects.

Methods

An open-label, two-period, fixed-sequence clinical study was conducted. Seventeen subjects were given a single oral dose of simvastatin 40 mg on day 1 and multiple oral doses of cilostazol 100 mg twice daily on days 2 to 5 followed by a single dose of cilostazol and simvastatin on day 6. Plasma concentrations of simvastatin and its active metabolite, simvastatin acid, were measured using liquid chromatography-tandem mass spectrometry for pharmacokinetic assessment. Moreover, serum lipid profiles under fasting conditions were determined.

Results

The geometric mean ratios of the area under the plasma concentration-time curve from

SUBMITTER: Kim JR 

PROVIDER: S-EPMC6343132 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature