Lipoprotein Particle Profiles, Standard Lipids, and Peripheral Artery Disease Incidence.

ABSTRACT:

Background

Despite strong and consistent prospective associations of elevated low-density lipoprotein (LDL) cholesterol concentration with incident coronary and cerebrovascular disease, data for incident peripheral artery disease (PAD) are less robust. Atherogenic dyslipidemia characterized by increased small LDL particle (LDL-P) concentration, rather than total LDL cholesterol content, along with elevated triglyceride-rich lipoproteins and low high-density lipoprotein (HDL) cholesterol (HDL-C), may be the primary lipid driver of PAD risk.

Methods

The study population was a prospective cohort study of 27 888 women ≥45 years old free of cardiovascular disease at baseline and followed for a median of 15.1 years. We tested whether standard lipid concentrations, as well as nucle

SUBMITTER: Aday AW 

PROVIDER: S-EPMC6343136 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature