Endothelial activation and injury by microparticles in patients with systemic lupus erythematosus and rheumatoid arthritis.

ABSTRACT:

Background

Endothelial activation and damage is commonly observed in patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) and is related to development of atherosclerosis and cardiovascular diseases. Different components of the immune system seem to participate in the endothelial injury, such as generation of autoantibodies and formation of immune complexes (ICs). Microparticles (MPs) and their immune complexes (MPs-ICs) are increased in the circulation of patients with SLE and RA; therefore, we propose these extracellular vesicles could interact and modulate the function of endothelial cells. Hence, the effect of MPs and MPs-ICs from patients with SLE and RA in endothelial cells was evaluated.

Methods

Macrovascular and microvascular endothelial cel

SUBMITTER: Atehortua L 

PROVIDER: S-EPMC6343289 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature