Role of t-PA and PAI-1 variants in temporal lobe epilepsy in Chinese Han population.

ABSTRACT:

Background

Epilepsy is one of the most common chronic disabling neurologic diseases. The purpose of our study was to investigate whether there is an association between t-PA (tissue plasminogen activator, rs2020918 and rs4646972), PAI-1 (plasminogen activator inhibitor 1, rs1799768) polymorphisms and susceptibility to temporal lobe epilepsy (TLE) in Chinese Han population.

Method

One hundred and twenty-one cases of patients who were diagnosed as TLE and 146 normal controls were enrolled and the genotypes of t-PA and PAI-1 were detected by polymerase chain reaction-ligase detection reaction (PCR-LDR) method after the genomic DNA being extracted from peripheral blood.

Result

There were significant differences for the genotypic frequencies at the two polymorphic sites in

SUBMITTER: Han W 

PROVIDER: S-EPMC6343363 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature