HLA-DQ strikes again: genome-wide association study further confirms HLA-DQ in the diagnosis of asthma among adults.

ABSTRACT:

Background

Asthma is a common chronic respiratory disease in children and adults. An important genetic component to asthma susceptibility has long been recognized, most recently through the identification of several genes (e.g., ORMDL3, PDE4D, HLA-DQ, and TLE4) via genome-wide association studies.

Objective

To identify genetic variants associated with asthma affection status using genome-wide association data.

Methods

We describe results from a genome-wide association study on asthma performed in 3855 subjects using a panel of 455 089 single nucleotide polymorphisms (SNPs).

Result

The genome-wide association study resulted in the prioritization of 33 variants for immediate follow-up in a multi-staged replication effort. Of these, a common polymorphism (rs927234

SUBMITTER: Lasky-Su J 

PROVIDER: S-EPMC6343489 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature