The multiscale structural and mechanical effects of mouse supraspinatus muscle unloading on the mature enthesis.

ABSTRACT: The musculoskeletal system is sensitive to its loading environment; this is of particular concern under conditions such as disuse, paralysis, and extended-duration space flight. Although structural and mechanical changes to tendon and bone following paralysis and disuse are well understood, there is a pressing need to understand how this unloading affects the bone-tendon interface (enthesis); the location most prone to tears and injury. We therefore elucidated these effects of unloading in the entheses of adult mice shoulders that were paralyzed for 21 days by treatment with botulinum toxin A. Unloading significantly increased the extent of mechanical failure and was associated with structural changes across hierarchical scales. At the millimeter scale, unloading caused bone loss. At the m

SUBMITTER: Deymier AC 

PROVIDER: S-EPMC6343501 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature