Molecular classification and subtype-specific drug sensitivity research of uterine carcinosarcoma under multi-omics framework.

ABSTRACT:

Objective

Uterine carcinosarcomas (UCSs) are aggressive rare tumors recognized as malignancies composed of metaplastic transformation of epithelial elements. Nay no comprehensive molecular classification has been applied to UCS to guide targeted therapies so far, which motivated us to subtyping UCS by aggregating multiple genomic platform data.

Methods

We classified UCS into three distinct subtypes with different clinicopathologic and molecular characterization by using similarity network fusion under consensus clustering framework (SNFCC⁺) to aggregate four genomic data platforms of 55 UCS patients. Differences across subtypes were extracted by functional enrichment, gene mutations and clinical features. Subtypes were further distinguished by putative biomarkers.

SUBMITTER: Lu X 

PROVIDER: S-EPMC6343709 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature