Hepatoprotective and anti-obesity effects of Korean blue honeysuckle extracts in high fat diet-fed mice.

ABSTRACT:

Purpose

This study aimed to study the protective effects and mechanism of Blue Honeysuckle (BH) extracts (Berries of Lonicera caerulea L.) on non-alcoholic fatty liver disease (NAFLD) and obesity risk factors in a high fat-diet (HFD) model.

Methods

Animals adapted to HFD were selected after 1 week of adaption period and divided into 6 groups (8 mice in each group; 40 HFD-fed mice and 8 normal fat pellet diet (NFD)-fed mice). After the end of 12 weeks of continuous oral administrations of 3 different dosages of BH extract, 400, 200 and 100 mg/kg, or metformin 250 mg/kg, dissolved in a volume of 10 mL/kg distilled water, the hepatoprotective, hypolipidemic, hypoglycemic, nephroprotective, and anti-obesity effects were analyzed.

Results

The BH extract improved fat densit

SUBMITTER: Chun YS 

PROVIDER: S-EPMC6343767 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature