Tumor-infiltrating T cells and PD-L1 expression in childhood malignant extracranial germ-cell tumors.

ABSTRACT: Although pediatric malignant extracranial germ-cell tumors (meGCTs) are among the most chemosensitive solid tumors, a group of patients relapse and die of disease. To identify new markers predicting clinical outcome, we examined the prognostic relevance of tumor-infiltrating T lymphocytes (TILs) and the expression of PD-1 and PD-L1 in a cohort of pediatric meGCTs by in situ immunohistochemistry. MeGCTs were variously infiltrated by T cell-subtypes according to the tumor subtype, tumor location and age at diagnosis. We distinguished three different phenotypes: i) tumors not infiltrated by T cells (immature teratomas and half of the yolk sac tumors), ii) tumors highly infiltrated by CD8⁺ T cells expressing PD-1, which identifies activated tumor-reactive T cells (seminomas a

SUBMITTER: Boldrini R 

PROVIDER: S-EPMC6343784 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature