IL-33 increases ST2⁺ Tregs and promotes metastatic tumour growth in the lungs in an amphiregulin-dependent manner.

ABSTRACT: Regulatory T cells (Tregs) facilitate primary and metastatic tumour growth through the suppression of anti-tumour immunity. Emerging evidence suggests a distinct role for Tregs in mediating tissue repair and barrier integrity in the lungs by IL-33 mediated production of the growth factor amphiregulin (AREG). Dependent on the type of cancer and local microenvironment, AREG may induce tumour cell proliferation, invasion, migration or resistance to apoptosis by signaling through the epidermal growth factor receptor (EGFR). We have found that IL-33 is dramatically increased in and around metastatic tumour foci in the lungs of mice bearing orthotopic murine mammary tumours. We observed that Tregs express significantly more of the IL-33 receptor, ST2, relative to conventional T cells, that ST2

SUBMITTER: Halvorsen EC 

PROVIDER: S-EPMC6343789 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature