Genomic and transcriptional Profiling of tumor infiltrated CD8⁺ T cells revealed functional heterogeneity of antitumor immunity in hepatocellular carcinoma.

ABSTRACT: As key players in HCC antitumor response, the functions of tumor infiltrated CD8⁺ T cells are significantly affected by surrounding microenvironment. A detailed profiling of their genomic and transcriptional changes could provide valuable insights for both future immunotherapy development and prognosis evaluation. We performed whole exome and transcriptome sequencing on tumor infiltrated CD8⁺ T cells and CD8⁺ T cells isolated from other tissue origins (peritumor tissues and corresponding PBMCs) in eight treatment-naive HCC patients. The results demonstrated that transcriptional changes, rather than genomic alterations were the main contributors to the functional alterations of CD8⁺ T cells in the process of tumor progression. The origins of CD8

SUBMITTER: Li Z 

PROVIDER: S-EPMC6343808 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature