Decreased total iron binding capacity upon intensive care unit admission predicts red blood cell transfusion in critically ill patients.

ABSTRACT:

Introduction

Red blood cell (RBC) transfusion is associated with poor clinical outcome in critically ill patients. We investigated the predictive value of biomarkers on intensive care units (ICU) admission for RBC transfusion within 28 days.

Methods

Critically ill patients (n = 175) who admitted to our ICU with organ dysfunction and an expected stay of ≥ 48 hours, without hemorrhage, were prospectively studied (derivation cohort, n = 121; validation cohort, n = 54). Serum levels of 12 biomarkers (hemoglobin, creatinine, albumin, interleukin-6 [IL-6], erythropoietin, Fe, total iron binding capacity [TIBC], transferrin, ferritin, transferrin saturation, folate, and vitamin B12) were measured upon ICU admission, days 7, 14, 21 and 28.

Results

Among the 12 biomarkers meas

SUBMITTER: Imaeda T 

PROVIDER: S-EPMC6343884 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature