RegQTLs: Single nucleotide polymorphisms that modulate microRNA regulation of gene expression in tumors.

ABSTRACT: Genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) associated with trait diversity and disease susceptibility, yet their functional properties often remain unclear. It has been hypothesized that SNPs in microRNA binding sites may disrupt gene regulation by microRNAs (miRNAs), short non-coding RNAs that bind to mRNA and downregulate the target gene. While several studies have predicted the location of SNPs in miRNA binding sites, to date there has been no comprehensive analysis of their impact on miRNA regulation. Here we investigate the functional properties of genetic variants and their effects on miRNA regulation of gene expression in cancer. Our analysis is motivated by the hypothesis that distinct alleles may cause differential binding (from m

SUBMITTER: Wilk G 

PROVIDER: S-EPMC6343932 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature