Divergent influences of the locus coeruleus on migraine pathophysiology.

ABSTRACT: Migraine is a common disabling neurological condition that is associated with several premonitory symptoms that can occur days before the headache onset. The most commonly reported premonitory symptom is marked fatigue that has been shown to be highly predictive of an ensuing migraine attack. The locus coeruleus (LC) is a key nucleus involved in arousal that has also been shown to impact pain processing. It provides one of the major sources of noradrenaline to the dorsal horn of the spinal cord and neocortex. Given the clinical association between migraine, sleep-wake regulation, and fatigue, we sought to determine whether LC modulation could impact migraine-related phenotypes in several validated preclinical models of migraine. To determine its role in migraine-related pain, we recorded d

SUBMITTER: Vila-Pueyo M 

PROVIDER: S-EPMC6343946 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature