Cannabinoid receptor-1 signaling contributions to sign-tracking and conditioned reinforcement in rats.

ABSTRACT:

Rationale

Endocannabinoids (eCBs) are critical gatekeepers of dopaminergic signaling, and disrupting cannabinoid receptor-1 (CB1) signaling alters DA dynamics to attenuate cue-motivated behaviors. Prior studies suggest that dopamine (DA) release plays a critical role in driving sign-tracking.

Objectives

Here, we determine whether systemic injections of rimonabant, a CB1 receptor inverse agonist, during Pavlovian lever autoshaping impair the expression of sign-tracking. We next examine whether rimonabant blocks the reinforcing properties of the Pavlovian lever cue in a conditioned reinforcement test.

Methods

In Exp. 1, we trained rats in Pavlovian lever autoshaping prior to systemic rimonabant injections (0, 1, 3 mg/kg) during early and late Pavlovian lever autoshaping

SUBMITTER: Bacharach SZ 

PROVIDER: S-EPMC6344029 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature