Type I interferons differentially modulate maternal host immunity to infection by Listeria monocytogenes and Salmonella enterica serovar Typhimurium during pregnancy.

ABSTRACT:

Problem

IFN-alpha receptor deficiency (IFNAR^-/- ) enhances immunity to Listeria monocytogenes (LM) and Salmonella enterica serovar Typhimurium (ST) in the non-pregnant state by inhibiting pathogen-induced immune cell death. However, the roles of IFNAR signaling in modulating immunity to infection during pregnancy are not well understood.

Method of study

C57BL/6J wild-type (WT) and IFNAR^-/- mice were infected systemically with LM or ST. Bacterial burden in spleen and individual placentas was enumerated at day 3 post-infection. Immune cell numbers and percentages were quantified in spleen and individual placentas, respectively, through flow cytometry. Cytokine expression in serum, spleen, and individual placentas was measured through cytometric bead array

SUBMITTER: Agbayani G 

PROVIDER: S-EPMC6344237 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature