Hepcidin Deficiency Protects Against Atherosclerosis.

ABSTRACT: Objective- Inflammatory stimuli enhance the progression of atherosclerotic disease. Inflammation also increases the expression of hepcidin, a hormonal regulator of iron homeostasis, which decreases intestinal iron absorption, reduces serum iron levels and traps iron within macrophages. The role of macrophage iron in the development of atherosclerosis remains incompletely understood. The objective of this study was to investigate the effects of hepcidin deficiency and decreased macrophage iron on the development of atherosclerosis. Approach and Results- Hepcidin- and LDL (low-density lipoprotein) receptor-deficient ( Hamp^-/-/ Ldlr^-/-) mice and Hamp^+/+/ Ldlr^-/- control mice were fed a high-fat diet for 21 weeks. Compared with control mice, Hamp

SUBMITTER: Malhotra R 

PROVIDER: S-EPMC6344241 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature