B Cell ADAM10 Controls Murine Lupus Progression through Regulation of the ICOS:ICOS Ligand Axis.

ABSTRACT: The role of ICOS and its ligand (ICOSL) have both been shown to be essential for proper humoral responses as well as autoimmune Ab development in mouse models of lupus. In this paper, we report a specific role for the metalloprotease ADAM10 on B cells in regulating both ICOSL and ICOS in a mouse model of increased humoral immunity using B6^mir146a-/- mice and a model of lymphoproliferative disease using the well-characterized lpr model. B6^lpr mice lacking ADAM10 on B cells (A10B^lpr) have decreased nodal proliferation and T cell accumulation compared with control B6^lpr mice. Additionally, A10B^lpr mice have a drastic reduction in autoimmune anti-dsDNA Ab production. In line with this, we found a significant reduction in follicular helper

SUBMITTER: Lownik JC 

PROVIDER: S-EPMC6344316 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature