A view behind the mask of sanity: meta-analysis of aberrant brain activity in psychopaths.

ABSTRACT: Psychopathy is a disorder of high public concern because it predicts violence and offense recidivism. Recent brain imaging studies suggest abnormal brain activity underlying psychopathic behavior. No reliable pattern of altered neural activity has been disclosed so far. This study sought to identify consistent changes of brain activity in psychopaths and to investigate whether these could explain known psychopathology. First, we used activation likelihood estimation (p < 0.05, corrected) to meta-analyze brain activation changes associated with psychopathy across 28 functional magnetic resonance imaging studies reporting 753 foci from 155 experiments. Second, we characterized the ensuing regions functionally by employing metadata of a large-scale neuroimaging database (p < 0.05, corrected).

SUBMITTER: Poeppl TB 

PROVIDER: S-EPMC6344321 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature