A combined analysis of genetically correlated traits identifies 187 loci and a role for neurogenesis and myelination in intelligence.

ABSTRACT: Intelligence, or general cognitive function, is phenotypically and genetically correlated with many traits, including a wide range of physical, and mental health variables. Education is strongly genetically correlated with intelligence (r_g = 0.70). We used these findings as foundations for our use of a novel approach-multi-trait analysis of genome-wide association studies (MTAG; Turley et al. 2017)-to combine two large genome-wide association studies (GWASs) of education and intelligence, increasing statistical power and resulting in the largest GWAS of intelligence yet reported. Our study had four goals: first, to facilitate the discovery of new genetic loci associated with intelligence; second, to add to our understanding of the biology of intelligence differences; third, to e

SUBMITTER: Hill WD 

PROVIDER: S-EPMC6344370 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature