Paths into Sepsis: Trajectories of Presepsis Healthcare Use.

ABSTRACT:

Rationale

Sepsis is a leading cause of death and disability whose heterogeneity is often cited as a key impediment to translational progress.

Objectives

To test the hypothesis that there are consequential and significant differences in sepsis outcomes that result from differences in a patient's clinical course leading up to sepsis hospitalization.

Methods

We conducted an observational cohort study of U.S. Health and Retirement Study (HRS) participants in Medicare (1998-2012) and U.S. Department of Veterans Affairs beneficiaries (2009). Using latent profile analysis, we identified patient subtypes based on trajectory of presepsis healthcare facility use. Subtypes were identified in the derivation cohort (1,512 sepsis hospitalizations among earlier HRS participants), th

SUBMITTER: Prescott HC 

PROVIDER: S-EPMC6344453 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature