Toxicity and possible mechanisms of action of honokiol from Magnolia denudata seeds against four mosquito species.

ABSTRACT: This study was performed to determine the toxicity and possible mechanism of the larvicidal action of honokiol, extracted from Magnolia denudata seeds, and its 10 related compounds against third-instar larvae of insecticide-susceptible Culex pipiens pallens, Aedes aegypti, and Aedes albopictus and Anopheles sinensis resistant to deltamethrin and temephos. Honokiol (LC₅₀, 6.13-7.37 mg/L) was highly effective against larvae of all of the four mosquito species, although the toxicity of the compound was lower than that of the synthetic larvicide temephos. Structure-activity relationship analyses indicated that electron donor and/or bulky groups at the ortho or para positions of the phenol were required for toxicity. Honokiol moderately inhibited acetylcholinesterase and caused a con

SUBMITTER: Wang Z 

PROVIDER: S-EPMC6344527 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature