Ontology highlight
ABSTRACT:
SUBMITTER: Liu X
PROVIDER: S-EPMC6344599 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Scientific reports 20190123 1
The E3 ubiquitin ligase Itch interacts with Foxo1 and targets it for ubiquitination and degradation during follicular helper T-cell differentiation, whereas the transcription factor Foxo1 plays a critical role in B-cell development. Thus, we proposed that Itch mediates B-cell differentiation. Unexpectedly, we found that Itch deficiency downregulated Foxo1 expression in B cells. Itch cKO (conditional knock out in B cells) mice had fewer pro-B cells in the bone marrow, more small resting IgM<sup>- ...[more]