Global Transcriptome Abnormalities of the Eutopic Endometrium From Women With Adenomyosis.

ABSTRACT:

Objective

Adenomyosis is a clinical disorder defined by the presence of endometrial glands and stroma within the myometrium, the pathogenesis of which is poorly understood. We postulate that dysregulation of genes and pathways in eutopic endometrium may predispose to ectopic implantation. No study, to our knowledge, has examined the global transcriptome of isolated eutopic endometrium from women with clinically significant adenomyosis.

Design

Laboratory-based study with full institutional review board approval and consents.

Material and methods

Endometrial sampling was performed on hysterectomy specimens (proliferative phase) from symptomatic women with pathologically confirmed diffuse adenomyosis (n = 3). Controls (n = 5) were normo-ovulatory patients without adenomy

SUBMITTER: Herndon CN 

PROVIDER: S-EPMC6344825 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature