L-caldesmon alters cell spreading and adhesion force in RANKL-induced osteoclasts.

ABSTRACT:

Background

Osteoclasts (OCs) are motile multinucleated cells derived from differentiation and fusion of hematopoietic progenitors of the monocyte-macrophage lineage that undergo a multistep process called osteoclastogenesis. The biological function of OCs is to resorb bone matrix for controlling bone strength and integrity, which is essential for bone development. The bone resorption function is based on the remodelling of the actin cytoskeleton into an F-actin-rich structure known as the sealing zone for bone anchoring and matrix degradation. Non-muscle caldesmon (l-CaD) is known to participate in the regulation of actin cytoskeletal remodeling, but its function in osteoclastogenesis remains unclear.

Methods/results

In this study, gain and loss of the l-CaD level in RAW264.

SUBMITTER: Chan CL 

PROVIDER: S-EPMC6345023 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature