CEACAM1 regulates the IL-6 mediated fever response to LPS through the RP105 receptor in murine monocytes.

ABSTRACT:

Background

Systemic inflammation and the fever response to pathogens are coordinately regulated by IL-6 and IL-1β. We previously showed that CEACAM1 regulates the LPS driven expression of IL-1β in murine neutrophils through its ITIM receptor.

Results

We now show that the prompt secretion of IL-6 in response to LPS is regulated by CEACAM1 expression on bone marrow monocytes. Ceacam1^-/- mice over-produce IL-6 in response to an i.p. LPS challenge, resulting in prolonged surface temperature depression and overt diarrhea compared to their wild type counterparts. Intraperitoneal injection of a ⁶⁴Cu-labeled LPS, PET imaging agent shows confined localization to the peritoneal cavity, and fluorescent labeled LPS is taken up by myeloid splenocytes and muscle endo

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC6345024 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature