Dilated cardiomyopathy-mediated heart failure induces a unique skeletal muscle myopathy with inflammation.

ABSTRACT:

Background

Skeletal muscle myopathy and exercise intolerance are diagnostic hallmarks of heart failure (HF). However, the molecular adaptations of skeletal muscles during dilated cardiomyopathy (DCM)-mediated HF are not completely understood.

Methods

Skeletal muscle structure and function were compared in wild-type (WT) and cardiac myosin binding protein-C null mice (t/t), which develop DCM-induced HF. Cardiac function was examined by echocardiography. Exercise tolerance was measured using a graded maximum treadmill running test. Hindlimb muscle function was assessed in vivo from measurements of plantar flexor strength. Inflammatory status was evaluated from the expression of inflammatory markers and the presence of specific immune cell types in gastrocnemius muscles. Muscle

SUBMITTER: Song T 

PROVIDER: S-EPMC6345027 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature