Enhanced phosphorylation of T153 in soluble tau is a defining biochemical feature of the A152T tau risk variant.

ABSTRACT: Pathogenic mutations in the tau gene (microtubule associated protein tau, MAPT) are linked to the onset of tauopathy, but the A152T variant is unique in acting as a risk factor for a range of disorders including Alzheimer's disease (AD), progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and dementia with Lewy bodies (DLB). In order to provide insight into the mechanism by which A152T modulates disease risk, we developed a novel mouse model utilizing somatic brain transgenesis with adeno-associated virus (AAV) to drive tau expression in vivo, and validated the model by confirming the distinct biochemical features of A152T tau in postmortem brain tissue from human carriers. Specifically, Tau^A152T-AAV mice exhibited increased tau phosphorylation that unlike ani

SUBMITTER: Carlomagno Y 

PROVIDER: S-EPMC6345061 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature