Investigating d-lysine stereochemistry for epigenetic methylation, demethylation and recognition.

ABSTRACT: Histone lysine methylation is regulated by N^ε-methyltransferases, demethylases, and N^ε-methyl lysine binding proteins. Thermodynamic, catalytic and computational studies were carried out to investigate the interaction of three epigenetic protein classes with synthetic histone substrates containing l- and d-lysine residues. The results reveal that out of the three classes, N^ε-methyl lysine binding proteins are superior in accepting lysines with the d-configuration.

SUBMITTER: Belle R 

PROVIDER: S-EPMC6345366 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature