Association Between Oxidation-Modified Lipoproteins and Coronary Plaque in Psoriasis.

ABSTRACT: RATIONALE:Psoriasis is a systemic inflammatory skin disease associated with cardiovascular disease and lipid dysfunction. However, traditional lipid parameters have limited prognostic value, whereas assessing oxidation-modified lipids in this inflammatory driven condition may capture additional risk. Recently, a study showed that psoriasis was associated with increased lipid-rich coronary plaques; therefore, investigating potential relationships with oxidation-modified lipids may speed understanding of increased cardiovascular disease in psoriasis. OBJECTIVE:To understand whether oxidation-modified lipids associate with traditional lipid phenotypes, cardiometabolic disease biomarkers, and total coronary plaque, with focus on noncalcified burden (NCB) by coronary computed tomographic angiog

SUBMITTER: Sorokin AV 

PROVIDER: S-EPMC6345554 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature