Mitochondrial complex III is essential for suppressive function of regulatory T cells.

ABSTRACT: Regulatory T cells (T_reg cells), a distinct subset of CD4⁺ T cells, are necessary for the maintenance of immune self-tolerance and homeostasis^1,2. Recent studies have demonstrated that T_reg cells exhibit a unique metabolic profile, characterized by an increase in mitochondrial metabolism relative to other CD4⁺ effector subsets^3,4. Furthermore, the T_reg cell lineage-defining transcription factor, Foxp3, has been shown to promote respiration^5,6; however, it remains unknown whether the mitochondrial respiratory chain is required for the T cell-suppression capacity, stability and survival of T_reg cells. Here we report that T_reg cell-specific ablation of mitochondrial respiratory chain

SUBMITTER: Weinberg SE 

PROVIDER: S-EPMC6345596 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature