Reprogramming Cdr2-Dependent Geometry-Based Cell Size Control in Fission Yeast.

ABSTRACT: How cell size is determined and maintained remains unclear, even in simple model organisms. In proliferating cells, cell size is regulated by coordinating growth and division through sizer, adder, or timer mechanisms or through some combination [1, 2]. Currently, the best-characterized example of sizer behavior is in fission yeast, Schizosaccharomyces pombe, which enters mitosis at a minimal cell size threshold. The peripheral membrane kinase Cdr2 localizes in clusters (nodes) on the medial plasma membrane and promotes mitotic entry [3]. Here, we show that the Cdr2 nodal density, which scales with cell size, is used by the cell to sense and control its size. By analyzing cells of different widths, we first show that cdr2⁺ cells divide at a fixed cell surface area. However, divis

SUBMITTER: Facchetti G 

PROVIDER: S-EPMC6345630 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature