Microbial-Driven Butyrate Regulates Jejunal Homeostasis in Piglets During the Weaning Stage.

ABSTRACT: Microbe-derived butyrate plays an important role in the gut health of young mammals during the weaning stage. A greater understanding of how butyrate regulates intestinal development is necessary for overcoming post-weaning diarrheal diseases. We aimed to investigate whether jejunal microbial metabolite butyrate modulates the apoptosis/proliferation balance and immune response in piglets during the post-weaning period of the first 3 weeks of life. On the one hand, during the first week post-weaning, the relative abundances of the dominant bacterial families Erysipelotrichaceae (P < 0.01) and Lachnospiraceae (P < 0.01) were increased, which induced decreases in both butyrate production (P < 0.05) and its receptor (G-protein coupled receptor 43) expression

SUBMITTER: Zhong X 

PROVIDER: S-EPMC6345722 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature